The Old Gold, without a win on the road all season, went behind early on to a Bobby Zamora goal, but Djibril Cisse’s red card for violent conduct allowed them to fight back and win.
Second-half goals from Matt Jarvis and Kevin Doyle ensured Wolves moved out of the bottom three, and level on points with their opponents who remain in danger at the wrong end of the table.
Newly-promoted Swansea and Norwich both took another massive stride towards Premier League safety as the both recorded important wins.
While Swansea came from behind to grab a second away win of the season, 2-1 at West Brom.
Marc-Antoine Fortune fired in from a corner in the 54th minute but the lead was short-lived as Gylfi Sigurdsson grabbed an equaliser a minute later before Danny Graham 59th minute goal settled the game.
Sunderland’s march up the table continued with a 1-0 win at Stoke thanks to a second-half James Mcclean strike. Robert Huth received his marching orders in the first-half for a dangerous challenge on David Meyler.